The Series reverted to Cincinnati for Game 6. Dickie Kerr, starting again for the White Sox, was less dominant than he had been in Game 3.
With the help of three Chicago errors, the Reds jumped out to a 4–0 lead before Chicago fought back. The Sox tied the game at 4–4 in the sixth, and that remained the score into extra innings. In the top of the tenth, scandal architect Chick Gandil drove in Buck Weaver to make it 5–4. Kerr closed it out to record his—and Chicago’s—second win.
For the Reds, Greasy Neale went 3-for-4 and pitcher Jimmy Ring game up only 1 run in 5 innings. The Reds’ Dutch Reuther, the hero of Game 1, gave up 4 earned runs in only 5 innings.